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BETTING

2025 NCAA Tournament Sweet Sixteen: Purdue vs. Houston Pick

Yesterday, I reviewed Thursday’s matchups using the AI Model. Today, we’ll take a look at the best bets for Friday’s college basketball slate in the Sweet 16. 

NCAAB Pick: Houston -7.5 (-110) at Caesars Sportsbook (check our Caesars Sportsbook Review)

Check out our other Friday picks:


Purdue Boilermakers vs. Houston Cougars

Friday, March 28, 2025 – 10:09 PM EDT at Lucas Oil Stadium


Purdue Won’t Get Anything Easy

The Purdue Boilermakers won’t get anything easy on the offensive end.

Purdue is a quality offense, shooting a 56.1% effective field goal percentage. However, the Boilermakers are in line to face a Houston defense that ranks No. 1 in the nation.

Houston has limited teams to 30.6% from deep and 44.3% from inside the arc. While Houston fouls at a higher rate, the Cougars have limited teams to 28.7% of offensive rebounds and have gained more than 21% of turnovers per game.

Purdue can shoot lights out when it gets open looks. But open looks will be hard to come by in this game.

Houston Will Find a Way

The Houston Cougars aren’t the most efficient offense inside the arc. After all, they’ve shot 48.8% from inside the arc this season.

That said, Purdue has watched teams shoot 56.2% from inside the arc this season. Additionally, Purdue has allowed a 52% effective field goal percentage, earned fewer turnovers, and allowed more offensive rebounds.

Give me Houston at -7.5. People thought Gonzaga had a chance against Houston last weekend, and that didn’t go well. Ultimately, Gonzaga matched up better than Purdue will.

NCAAB Pick: Houston -7.5 (-110) at Caesars Sportsbook 

*21+ Seek help with a gambling addiction at 1-800-Gambler

*The line and/or odds referenced in this article might have changed since the content was published. For the latest information on line movements, visit OddsTrader’s free betting odds tool.

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