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NFL Week 1 Odds: Latest NFL Spreads, Totals & Best Lines Available

Patrick Mahomes Kansas City Chiefs NFL player
Patrick Mahomes 15 of the Kansas City Chiefs throws a pass against the Philadelphia Eagles during the first half in Super Bowl LVII at State Farm Stadium on February 12 2023 Gregory ShamusGetty ImagesAFP

The 2023 NFL regular season is set to kick off with a bang, as the Super Bowl champions Kansas City Chiefs take on the Detroit Lions on September 7. Last season, both teams boasted impressive offenses, and this matchup promises to be a high-scoring affair even with the Travis Kelce injury news.

On Tuesday afternoon, the line in the Lions-Chiefs game dropped from -6.5 to as low as -4.5 (depending on where you shop) after Kelce was scratched from the game due to a hyperextended knee.

Other notable matchups in Week 1 include the San Francisco 49ers facing off against the competitive Pittsburgh Steelers, as the Niners have doubts surrounding their quarterback position. Meanwhile, the Dallas Cowboys take on the New York Giants on Sunday Night Football. 

However, the most talked-about game is likely to be Aaron Rodgers’ debut as a member of the New York Jets on Monday Night Football against Josh Allen and the Buffalo Bills in what will be a matchup between two of the favorites to win the MVP.


NFL Week 1 Odds

Below, you can find the complete list of NFL Week 1 odds. Remember to bookmark this page and check back regularly, as we’ll be updating the odds throughout the off-season

MatchupDateTimeSpreadOver/Under
Ravens vs. ChiefsThursday, September 0508:20 PM ETChiefs -2.5 (-115)46.5
Packers vs. Eagles (Brazil)Friday, September 0608:15 PM ETEagles -1 (-110)49.0
Jaguars vs. DolphinsSunday, September 0801:00 PM ETDolphins -3.5 (-110)49.0
Steelers vs. FalconsSunday, September 0801:00 PM ETFalcons -3 (-105)43
Vikings vs. GiantsSunday, September 0801:00 PM ETGiants -1 (-110)41
Panthers vs. SaintsSunday, September 0801:00 PM ETSaints -5 (-110)40
Patriots vs. BengalsSunday, September 0801:00 PM ETBengals -9 (-110)42
Titans vs. BearsSunday, September 0801:00 PM ETBears -4.5 (-110)44
Cardinals vs. BillsSunday, September 0801:00 PM ETBills -7 (-110)48
Texans vs. ColtsSunday, September 0801:00 PM ETTexans -1.5 (-110)48
Raiders vs. ChargersSunday, September 0804:05 PM ETChargers -3.5 (-110)43
Broncos vs. SeahawksSunday, September 0804:05 PM ETSeahawks -5 (-110)42
Commanders vs. BuccaneersSunday, September 0804:25 PM ETBuccaneers -4 (-110)41
Cowboys vs. BrownsSunday, September 0804:25 PM ETCowboys -1 (-115)44
Rams vs. LionsSunday, September 0808:20 PM ETLions -3.5 (-110)51
Jets vs. 49ersMonday, September 0908:15 PM ET49ers -5 (-110)45.5

*Odds via Caesars Sportsbook (check our Caesars Sportsbook Review) as of September 6, 2023.


Best NFL Week 1 Spread Available

Matchup Current Best Spread Available
Ravens vs. ChiefsChiefs -2.5 (-115) at Bet365
Packers vs. EaglesSaints -1 (-110) at Caesars Sportsbook
Jaguars vs. DolphinsDolphins -3.5 (-110) at Caesars Sportsbook
Steelers vs. FalconsFalcons -3 (-105) at Caesars Sportsbook
Vikings vs. GiantsGiants -1 (-110) at Caesars Sportsbook
Panthers vs. SaintsSaints -5 (-110) at Caesars Sportsbook
Patriots vs. BengalsBengals -9 (-110) at Caesars Sportsbook
Titans vs. BearsBears -4.5 (-110) at Caesars Sportsbook
Cardinals vs. BillsBills -7 (-110) at Caesars Sportsbook
Texans vs. ColtsTexans -1.5 (-110) at Bet365
Raiders vs. ChargersChargers -3.5 (-110) at Caesars Sportsbook
Broncos vs. SeahawksSeahawks -5 (-110) at Caesars Sportsbook
Commanders vs. BuccaneersBuccaneers -4 (-110) at Caesars Sportsbook
Cowboys vs. BrownsCowboys -1 (-110) at Bet365
Rams vs. LionsLions -3.5 (-110) at Caesars Sportsbook
Jets vs. 49ers49ers -5.5 (-110) at Caesars Sportsbook

More Weekly NFL Odds Previews

Eager to explore the upcoming NFL schedule for the most recent odds or curious about the odds of a game that has already taken place? Check out our odds preview covering all 18 weeks of the NFL regular season!


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