NFL Picks, Predictions, and Expert Best Bets for This Week

Welcome to OddsTrader, your trusted destination for expert NFL picks including the best moneyline, spread, and over/under bets for each week of the 2025 NFL season. Whether you’re a seasoned bettor or just starting out, our weekly insights provide data-backed, free NFL picks that give you a competitive edge.

We analyze a variety of key factors, such as matchup history, injury reports, recent team performance, weather forecasts, and more to help you make informed decisions. From NFL best bets to long-term futures, OddsTrader has you covered.

NFL Expert Picks for This Week

Each week, our NFL betting experts provide free predictions for every matchup on the schedule. These aren’t just opinions based on gut feelings. Our NFL picks are backed by five years of historical NFL data, real-time analytics, and market movement trends.

We examine everything from home vs. away splits to team trends against the spread to uncover high-value opportunities. Whether you’re betting on the spread, moneyline, or totals, our weekly slate of predictions is designed to help you beat the books.

Today’s Free NFL Picks

Using insights from our NFL computer picks this week, here are our top best NFL bets for Week 16:

Vikings -2.5 (-114) at Giants
Every year, there’s a team that fails to meet expectations but then finishes the season strong. It looks like the Vikings are this year’s version. Coming off a blowout win vs the Commanders and impressive upset against the Cowboys, look for the Vikings to take care of business against a tanking Giants team.

Jaguars/Broncos Over 46.5 (-110)

The Jaguars offense is firing on all cylinders right now. This team has put up 36 and 48 points in their last two games. Since their Week 8 bye, Jacksonville has scored 25+ points in all seven of their games. The Broncos defense is good, but they’ve played in some shootouts at home, including last week vs the Packers in a 34-26 win.

Lions -7 (-109) vs Steelers

The Lions are in a must-win game at home against a Steelers team that is much worse than their record. Pittsburgh has wins against below .500 teams like Dolphins, Bengals, Browns, and Vikings. The Lions are much better at home, and should pour on points in this spot. It wouldn’t surprise me to see this turn into a blowout.

NFL Computer Picks

At OddsTrader, we leverage proprietary AI and machine learning algorithms to simulate thousands of game outcomes. Our NFL computer picks deliver unbiased projections for:

• Spread: Predicting which team covers the line
• Totals (Over/Under): Forecasting the combined points scored
• Moneyline: Identifying the straight-up winner

These free NFL predictions are updated throughout the week to reflect real-time changes in player availability, odds movement, and public betting percentages. Each of our NFL best bets is heavily researched and informed by pertinent data, including head-to-head matchups, weather conditions, recent performance, and much more.

NFL Expert Picks Against the Spread (ATS)

Against the Spread (ATS) betting is one of the most popular ways to wager on NFL games. Instead of simply picking a winner, you’re betting on whether a team will cover the spread—either winning by a certain number of points or losing by fewer than expected.

For example, if the Packers are -3 favorites, they must win by more than 3 points to cover the spread. If they win by 2 or lose, they fail to cover.

Our ATS picks are informed by betting trends, head-to-head results, and market shifts to spot value plays others might miss.

NFL Over/Under Picks

Over/Under betting, also known as totals, focuses on the combined score of both teams in a game. If the total is set at 48.5, you’re betting whether the final score will be over or under that number.

Our data models analyze offensive and defensive metrics, pace of play, weather, and matchup history to give you accurate Over/Under picks.

NFL Moneyline Predictions

Moneyline bets are the most straightforward; you’re simply picking which team will win the game outright. No spreads involved. These are great for parlays or betting on underdogs with upset potential.

We provide NFL moneyline picks for every matchup, highlighting where the odds offer value based on simulation results and sharp money trends.

NFL Parlays

A parlay bet combines multiple individual bets into one ticket. All legs must win for the bet to cash, but the payout increases with each added selection. A same-game parlay (SGP) allows you to bet on different outcomes within a single game—like a team to win, the total to go Over, and a player to score a touchdown.

NFL Predictions: Playoffs and Super Bowl Futures

Beyond weekly picks, OddsTrader also provides season-long NFL futures, long-term bets that predict the outcome of key awards and events such as:

• NFL MVP
• Super Bowl Winner
• AFC/NFC Champions
• Rookie of the Year

Explore our latest player futures and league futures to see where the value lies as the season progresses.

NFL News and Betting Updates

Smart NFL bettors know that the edge often comes from up-to-the-minute information. Here’s what we track every week:

• Injury Reports: Key player absences impact point spreads and totals
• NFL Line Movements: Follow sharp money and market overreactions
• Game Weather Conditions: Wind and rain can drastically affect totals and passing performance

Stay ahead of the curve by checking back frequently for updates.

NFL Betting Tools and Resources

Maximize your betting edge by using OddsTrader’s powerful tools:

• Our NFL odds comparison tool lets you shop the best lines across top sportsbooks in real-time.
• Visit our NFL betting analysis hub for in-depth breakdowns, betting trends, and model-driven projections.
• We offer in-depth ATS season records to enhance your ability to spot value bets throughout the entire season.

About Our NFL Picks

At OddsTrader, our NFL picks are built using a combination of:

• Historical data analysis
• Advanced predictive modeling
• Contrarian betting strategies
• Trend tracking and matchup analytics

We prioritize transparency and backtest all our predictions so you can follow the data behind the picks. No guesswork—just smart betting insights.

Live NFL Betting Predictions

Our proprietary tool is always staying up to date with the latest odds, providing updated projections based on what’s happening in the game. This makes OddsTrader also useful for NFL live betting, where you’re placing in-game wagers. 

Do you want to ride with a heavy favorite on the moneyline after they got off to a slow start in the first quarter? OddsTrader will let you know which sportsbook is offering value.

Get Your NFL Best Bets Now

We update our NFL picks feed daily, ensuring you’re always working with the most current data and analysis. From Thursday Night Football to Monday Night matchups, you’ll always have expert insights at your fingertips.

NFL Picks FAQs

Can I bet on NFL games online legally?

Online sports betting is now legal in more than 38 states. You can place NFL wagers via mobile apps and websites in lots of states. Our picks comparison grid has a filter tool, allowing you to see which betting sites are available in your state and find the best lines.

What are the best free NFL picks today?

Check out our top 3 picks above, updated weekly using both expert analysis and computer simulations. Our best bets are always free.

Are expert picks better than computer picks?

Both have value. Expert picks factor in human context and experience, while computer picks rely on pure data. Using both provides a more balanced approach. 

But one key advantage of our NFL computer picks is their objectivity, reducing the influence of personal bias. Casual fans and even professional handicappers often let their preferences for certain teams or players influence their decisions. Our picks ensure precision and impartiality, so you can place the best bets possible throughout the entire season.

How can I find value in NFL bets?

Look for line discrepancies, public betting trends, injury updates, and sharp movement. Tools like our odds comparison help you spot value quickly.

When is the best time to bet on NFL games?

Early in the week offers softer lines, but waiting until game day lets you capitalize on late-breaking news. Timing depends on the bet type.

Where can I get guaranteed or premium NFL picks?

No pick is ever truly “guaranteed,” but OddsTrader offers premium features, deeper analysis, and enhanced tools to improve your betting strategy.